MolNFT v1 · #12722 · protein

Structure of the TSG101 uev domain

1KPP · Tumor susceptibility gene 101 protein: “Structure of the TSG101 uev domain”. Solution nmr, 3 pockets (best druggability 0.60). MolNFT v1 #12722 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1KPP
Type: protein
Length: 144 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tumor susceptibility gene 101 protein
UniProt: Q99816
Pockets: 3 · best druggability 0.60

Structure

solution nmr · 1 distinct chain · 26% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tumor susceptibility gene 101 protein	protein	144	26% helix, 21% strand	Q99816

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.60	0.89	16	empty
2	108	0.39	0.75	21	empty
3	52	0.31	0.76	18	empty

Compared structures

1KPP · Structure of the Tsg101 UEV domain · the same entry in another collection · chain A against A, TM-score 1.00
Q99816 · AlphaFold monomer V2.0 prediction for tumor susceptibility gene 101 protein (Q99816) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99816
Elsewhere: RCSB PDB 1KPP · PDBe 1KPP · UniProt Q99816

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