MolNFT v1 · #127216 · protein
Crystal structure of arabidopsis thaliana RNA editing factor MORF1, space group P2(1)
5MPX · Multiple organellar RNA editing factor 1, mitochondrial: “Crystal structure of arabidopsis thaliana RNA editing factor MORF1, space group P2(1)”. X-ray diffraction, 1 ligand (SO4), 10 pockets (best druggability 0.63). MolNFT v1…
- PDB
- 5MPX
- Type
- protein
- Length
- 460 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multiple organellar RNA editing factor 1, mitochondrial
- UniProt
- O49429
- Ligands
- SO4
- Pockets
- 10 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Multiple organellar RNA editing factor 1, mitochondrial | protein | 115 | 28% helix, 31% strand | O49429 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 7 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 447 | 0.63 | 0.77 | 48 | empty |
| 2 | 209 | 0.61 | 0.82 | 31 | empty |
| 3 | 214 | 0.60 | 0.81 | 31 | empty |
| 4 | 157 | 0.44 | 0.75 | 22 | empty |
| 5 | 58 | 0.38 | 0.80 | 19 | empty |
Interfaces
6 interfaces between chains.
- A–D · 838 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 802 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 796 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 783 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 489 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 5MPX · Crystal structure of Arabidopsis thaliana RNA editing factor MORF1, space group P2(1) · the same entry in another collection · chain A against A, TM-score 1.00
- O49429 · AlphaFold monomer V2.0 prediction for multiple organellar RNA editing factor 1… · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O49429
- Elsewhere: RCSB PDB 5MPX · PDBe 5MPX · UniProt O49429
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