MolNFT v1 · #127096 · protein
The X-ray structure of the effector domain of the transcriptional regulator ampr of pseudomonas aeruginosa
5MMH · Hth-type transcriptional activator ampr: “The X-ray structure of the effector domain of the transcriptional regulator ampr of pseudomonas aeruginosa”. X-ray diffraction, 5 pockets (best druggability 0.73). MolNFT v1 #127096 on…
- PDB
- 5MMH
- Type
- protein
- Length
- 812 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hth-type transcriptional activator ampr
- UniProt
- P24734
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hth-type transcriptional activator ampr | protein | 206 | 39% helix, 27% strand | P24734 |
| B | Hth-type transcriptional activator ampr | protein | 201 | 41% helix, 27% strand | P24734 |
| C | Hth-type transcriptional activator ampr | protein | 203 | 38% helix, 26% strand | P24734 |
| D | Hth-type transcriptional activator ampr | protein | 202 | 40% helix, 26% strand | P24734 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 835 | 0.73 | 0.78 | 89 | empty |
| 2 | 730 | 0.71 | 0.78 | 88 | empty |
| 3 | 69 | 0.68 | 0.95 | 20 | empty |
| 4 | 197 | 0.58 | 0.81 | 39 | empty |
| 5 | 117 | 0.36 | 0.73 | 23 | empty |
Interfaces
4 interfaces between chains.
- A–C · 536 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 519 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 438 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 363 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5MMH · The X-Ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of… · the same entry in another collection · chain D against D, TM-score 1.00
- P24734 · AlphaFold monomer V2.0 prediction for hth-type transcriptional activator ampr (P24734) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24734
- Elsewhere: RCSB PDB 5MMH · PDBe 5MMH · UniProt P24734
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