MolNFT v1 · #127093 · protein
Crystal structure of crebbp bromodomain complexd with US46C
5MME · Creb-binding protein: “Crystal structure of crebbp bromodomain complexd with US46C”. X-ray diffraction, 1 ligand (8Q6), 3 pockets (best druggability 0.53). MolNFT v1 #127093 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5MME
- Type
- protein
- Length
- 238 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Creb-binding protein
- EC
- 2.3.1.48
- UniProt
- Q92793
- Ligands
- 8Q6
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Creb-binding protein (EC 2.3.1.48) | protein | 119 | 66% helix, 0% strand | Q92793 |
Ligands and binding sites
- 8Q6 · dimethyl 5-[(5-ethanoyl-2-ethoxy-phenyl)amino]benzene-1,3-dicarboxylate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.53 | 0.85 | 19 | 8Q6 |
| 2 | 195 | 0.52 | 0.77 | 24 | empty |
| 3 | 103 | 0.48 | 0.80 | 20 | 8Q6 |
Interfaces
1 interface between chains.
- A–B · 209 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92793
- Elsewhere: RCSB PDB 5MME · PDBe 5MME · UniProt Q92793
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.