MolNFT v1 · #127066 · protein

Plantago major multifunctional oxidoreductase V150M mutant in complex with progesterone and NADP+

5MLM · Progesterone 5-beta-reductase: “Plantago major multifunctional oxidoreductase V150M mutant in complex with progesterone and NADP+”. X-ray diffraction, 2 ligands (STR, NAP), 1 pocket (best druggability 0.83). MolNFT v1 #127066 on…

PDB: 5MLM
Type: protein
Length: 364 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Progesterone 5-beta-reductase
EC: 1.1.1.145
UniProt: D6N9X1
Ligands: STR, NAP
Pockets: 1 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Progesterone 5-beta-reductase (EC 1.1.1.145)	protein	364	42% helix, 13% strand	D6N9X1

Ligands and binding sites

STR · Progesterone · ligand · chains A
NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	450	0.83	0.91	63	STR, NAP

Compared structures

5MLM · Plantago Major multifunctional oxidoreductase V150M mutant in complex with progesterone… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D6N9X1
Elsewhere: RCSB PDB 5MLM · PDBe 5MLM · UniProt D6N9X1

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