MolNFT v1 · #127060 · protein

Crystal structure of rat prorenin

5MLG: “Crystal structure of rat prorenin”. X-ray diffraction, 1 ligand (NAG), 4 pockets (best druggability 0.56). MolNFT v1 #127060 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5MLG
Type: protein
Length: 364 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Renin
EC: 3.4.23.15
UniProt: P08424
Ligands: NAG
Pockets: 4 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Renin (EC 3.4.23.15)	protein	364	17% helix, 40% strand	P08424

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	193	0.56	0.79	39	empty
2	62	0.46	0.83	17	empty
3	79	0.32	0.74	19	empty
4	51	0.24	0.73	12	empty

Modifications

Observed in the structure: 3 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

5MLG · Crystal structure of rat prorenin · the same entry in another collection · chain A against A, TM-score 1.00
P08424 · AlphaFold monomer V2.0 prediction for renin (P08424) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08424
Elsewhere: RCSB PDB 5MLG · PDBe 5MLG · UniProt P08424

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