MolNFT v1 · #127037 · protein

Crystal structure of mouse prorenin

5MKT · Renin-1: “Crystal structure of mouse prorenin”. X-ray diffraction, 1 ligand (NAG), 3 pockets (best druggability 0.65). MolNFT v1 #127037 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5MKT
Type: protein
Length: 329 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Renin-1
EC: 3.4.23.15
UniProt: P06281
Ligands: NAG
Pockets: 3 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Renin-1 (EC 3.4.23.15)	protein	329	14% helix, 38% strand	P06281

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.65	0.86	35	empty
2	329	0.65	0.80	37	empty
3	277	0.58	0.78	41	empty

Modifications

Observed in the structure: 2 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

5MKT · Crystal structure of mouse prorenin · the same entry in another collection · chain A against A, TM-score 1.00
P06281 · AlphaFold monomer V2.0 prediction for renin-1 (P06281) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06281
Elsewhere: RCSB PDB 5MKT · PDBe 5MKT · UniProt P06281

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.