MolNFT v1 · #126875 · protein
Human SIRT6 in complex with small molecule UBCS40
5MFZ: “Human SIRT6 in complex with small molecule UBCS40”. X-ray diffraction, 4 ligands (AR6, 7M9, ZN). MolNFT v1 #126875 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5MFZ
- Type
- protein
- Length
- 557 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q8N6T7
- Ligands
- AR6, 7M9, ZN, SO4
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 282 | — | Q8N6T7 |
| B | — | protein | 275 | — | Q8N6T7 |
Ligands and binding sites
- AR6 · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · ligand · 2 copies · chains A, B
- 7M9 · 1-pyrrolo[1,2-a]quinoxalin-4-ylnaphthalen-2-ol · ligand · chains A
- ZN · Zinc ion · metal · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 8 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5MFZ · Human Sirt6 in complex with small molecule UBCS40 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N6T7
- Elsewhere: RCSB PDB 5MFZ · PDBe 5MFZ · UniProt Q8N6T7
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