MolNFT v1 · #126827 · protein

Structure of an E333Q variant of the GH99 endo-alpha-mannanase from bacteroides xylanisolvens in complex with glc-alpha-1,3-(3R,4R,5R)-5- (HYDROXYMETHYL)CYCLOHEX-1,2-ene-3,4-diol

5MEL · Glycosyl hydrolase family 71: “Structure of an E333Q variant of the GH99 endo-alpha-mannanase from bacteroides xylanisolvens in complex with…”. X-ray diffraction, 2 ligands (7LQ, GLC), 2 pockets (best druggability 0.49). MolNFT v1…

PDB: 5MEL
Type: protein
Length: 347 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycosyl hydrolase family 71
UniProt: D6D1V7
Ligands: 7LQ, GLC
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycosyl hydrolase family 71	protein	347	34% helix, 17% strand	D6D1V7

Ligands and binding sites

7LQ · (1~{R},2~{R},6~{R})-6-(hydroxymethyl)cyclohex-3-ene-1, 2-diol · ligand · chains A
GLC · alpha-D-glucopyranose · sugar · chains A
ACT · Acetate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	155	0.49	0.77	28	GLC, 7LQ
2	59	0.35	0.78	18	empty

Compared structures

5MEL · Structure of an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D6D1V7
Elsewhere: RCSB PDB 5MEL · PDBe 5MEL · UniProt D6D1V7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.