MolNFT v1 · #126736 · protein
Ceue (H227A, Y288F variant) a periplasmic protein from campylobacter jejuni
5MBU · Enterochelin uptake periplasmic binding protein: “Ceue (H227A, Y288F variant) a periplasmic protein from campylobacter jejuni”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #126736 on GenesisL1: 3D structure…
- PDB
- 5MBU
- Type
- protein
- Length
- 852 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Enterochelin uptake periplasmic binding protein
- UniProt
- Q0P8Q4
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Enterochelin uptake periplasmic binding protein | protein | 285 | 39% helix, 21% strand | Q0P8Q4 |
| B | Enterochelin uptake periplasmic binding protein | protein | 286 | 41% helix, 21% strand | Q0P8Q4 |
| C | Enterochelin uptake periplasmic binding protein | protein | 281 | 42% helix, 21% strand | Q0P8Q4 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 572 | 0.73 | 0.81 | 63 | empty |
| 2 | 635 | 0.66 | 0.75 | 72 | empty |
| 3 | 271 | 0.64 | 0.81 | 51 | empty |
| 4 | 273 | 0.60 | 0.79 | 35 | empty |
| 5 | 208 | 0.59 | 0.80 | 37 | empty |
Interfaces
3 interfaces between chains.
- A–C · 477 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 317 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 315 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5MBU · CeuE (H227A, Y288F variant) a periplasmic protein from Campylobacter jejuni · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0P8Q4
- Elsewhere: RCSB PDB 5MBU · PDBe 5MBU · UniProt Q0P8Q4
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