MolNFT v1 · #12664 · protein

BSE634I restriction endonuclease

1KNV: “BSE634I restriction endonuclease”. X-ray diffraction, 1 ligand (CL), 6 pockets (best druggability 0.65). MolNFT v1 #12664 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1KNV
Type: protein
Length: 581 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BSE634I restriction endonuclease
EC: 3.1.21.4
UniProt: Q8RT53
Ligands: CL
Pockets: 6 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BSE634I restriction endonuclease (EC 3.1.21.4)	protein	290	50% helix, 15% strand	Q8RT53
B	BSE634I restriction endonuclease (EC 3.1.21.4)	protein	291	47% helix, 16% strand	Q8RT53

Ligands and binding sites

CL · Chloride ion · ion · 5 copies · chains A, B
ACT · Acetate ion · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	463	0.65	0.78	53	empty
2	497	0.62	0.75	55	empty
3	452	0.61	0.76	48	empty
4	84	0.40	0.78	16	empty
5	75	0.37	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 1619 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1KNV · Bse634I restriction endonuclease · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8RT53
Elsewhere: RCSB PDB 1KNV · PDBe 1KNV · UniProt Q8RT53

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