MolNFT v1 · #126601 · protein
Structure of human O-glcnac hydrolase
5M7R · Protein O-glcnacase: “Structure of human O-glcnac hydrolase”. X-ray diffraction, 8 pockets (best druggability 0.79). MolNFT v1 #126601 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5M7R
- Type
- protein
- Length
- 936 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein O-glcnacase
- EC
- 3.2.1.169, 3.2.1.-
- UniProt
- O60502
- Pockets
- 8 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein O-glcnacase (EC 3.2.1.169, 3.2.1.-) | protein | 466 | 48% helix, 9% strand | O60502 |
| B | Protein O-glcnacase (EC 3.2.1.169, 3.2.1.-) | protein | 470 | 47% helix, 9% strand | O60502 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1123 | 0.79 | 0.81 | 83 | empty |
| 2 | 614 | 0.75 | 0.81 | 65 | empty |
| 3 | 367 | 0.67 | 0.80 | 50 | empty |
| 4 | 105 | 0.59 | 0.86 | 22 | empty |
| 5 | 53 | 0.33 | 0.78 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 5169 Ų buried · 35 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60502
- Elsewhere: RCSB PDB 5M7R · PDBe 5M7R · UniProt O60502
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