MolNFT v1 · #126215 · protein

Turnip yellow mosaic virus PROTEASE/DEUBIQUITINASE domain, DELTAC5 mutant

5LW5 · RNA replicase polyprotein: “Turnip yellow mosaic virus PROTEASE/DEUBIQUITINASE domain, DELTAC5 mutant”. X-ray diffraction, 2 pockets (best druggability 0.53). MolNFT v1 #126215 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 5LW5
Type: protein
Length: 288 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA replicase polyprotein
EC: 2.1.1.-, 3.4.22.-, 3.6.4.-, 2.7.7.48
UniProt: P10358
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA replicase polyprotein (EC 2.1.1.-, 3.4.22.-, 3.6.4.-, 2.7.7.48)	protein	145	32% helix, 25% strand	P10358
B	RNA replicase polyprotein (EC 2.1.1.-, 3.4.22.-, 3.6.4.-, 2.7.7.48)	protein	143	33% helix, 24% strand	P10358

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	242	0.53	0.76	32	empty
2	98	0.39	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 246 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5LW5 · Turnip yellow mosaic virus PROTEASE/DEUBIQUITINASE domain, DELTAC5 mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10358
Elsewhere: RCSB PDB 5LW5 · PDBe 5LW5 · UniProt P10358

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