MolNFT v1 · #126171 · protein
Structures of dhbn domain of pelecanus crispus blm helicase
5LUS: “Structures of dhbn domain of pelecanus crispus blm helicase”. X-ray diffraction, 5 pockets (best druggability 0.77). MolNFT v1 #126171 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LUS
- Type
- protein
- Length
- 494 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Blm helicase
- UniProt
- A0A091SV96
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, I, J | Blm helicase | protein | 50 | 76% helix, 0% strand | A0A091SV96 |
| D, E, G, H | Blm helicase | protein | 49 | 73% helix, 0% strand | A0A091SV96 |
| F | Blm helicase | protein | 48 | 75% helix, 0% strand | A0A091SV96 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1177 | 0.77 | 0.79 | 74 | empty |
| 2 | 295 | 0.63 | 0.80 | 37 | empty |
| 3 | 71 | 0.44 | 0.81 | 19 | empty |
| 4 | 62 | 0.43 | 0.82 | 16 | empty |
| 5 | 73 | 0.42 | 0.80 | 17 | empty |
Interfaces
24 interfaces between chains.
- A–B · 1386 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 1353 Ų buried · 4 hydrogen bonds · protein-protein
- I–J · 1310 Ų buried · 4 hydrogen bonds · protein-protein
- G–H · 1302 Ų buried · 5 hydrogen bonds · protein-protein
- E–F · 1267 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5LUS · Structures of DHBN domain of Pelecanus crispus BLM helicase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A091SV96
- Elsewhere: RCSB PDB 5LUS · PDBe 5LUS · UniProt A0A091SV96
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