MolNFT v1 · #126124 · protein

Citrate-bound pichia angusta ATG18

5LTG · Autophagy-related protein 18: “Citrate-bound pichia angusta ATG18”. X-ray diffraction, 1 ligand (PO4), 5 pockets (best druggability 0.79). MolNFT v1 #126124 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LTG
Type: protein
Length: 632 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Autophagy-related protein 18
UniProt: Q5QA94
Ligands: PO4
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 58% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Autophagy-related protein 18	protein	314	0% helix, 58% strand	Q5QA94
B	Autophagy-related protein 18	protein	318	0% helix, 58% strand	Q5QA94

Ligands and binding sites

PO4 · Phosphate ion · ion · 2 copies · chains A, B
FLC · Citrate anion · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	661	0.79	0.84	60	empty
2	612	0.78	0.84	56	empty
3	355	0.73	0.84	50	empty
4	319	0.57	0.76	36	empty
5	76	0.36	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 523 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5LTG · Citrate-bound Pichia angusta Atg18 · the same entry in another collection · chain A against A, TM-score 1.00
Q5QA94 · AlphaFold monomer V2.0 prediction for autophagy-related protein 18 (Q5QA94) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5QA94
Elsewhere: RCSB PDB 5LTG · PDBe 5LTG · UniProt Q5QA94

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