MolNFT v1 · #126097 · protein

Crystal structure of SPF45 uhm domain with cyclic peptide inhibitor

5LSO · Splicing factor 45: “Crystal structure of SPF45 uhm domain with cyclic peptide inhibitor”. X-ray diffraction. MolNFT v1 #126097 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LSO
Type: protein
Length: 218 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Splicing factor 45; Lys-ser-arg-TRP-asp-glu
UniProt: Q96I25

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Splicing factor 45	protein	103	27% helix, 28% strand	Q96I25
C, D	Lys-ser-arg-TRP-asp-glu	protein	6	0% helix, 17% strand	—

Interfaces

4 interfaces between chains.

A–C · 443 Å² buried · 15 hydrogen bonds · protein-protein
B–D · 430 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 343 Å² buried · 4 hydrogen bonds · protein-protein
C–B · 82 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 2 isopeptide (isopeptide).

Compared structures

5LSO · Crystal structure of SPF45 UHM domain with cyclic peptide inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Q96I25 · AlphaFold monomer V2.0 prediction for splicing factor 45 (Q96I25) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96I25
Elsewhere: RCSB PDB 5LSO · PDBe 5LSO · UniProt Q96I25

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