MolNFT v1 · #126062 · protein
Structure of mono-zinc mcr-1 in P21 space group
5LRN · Phosphatidylethanolamine transferase mcr-1: “Structure of mono-zinc mcr-1 in P21 space group”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.84). MolNFT v1 #126062 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5LRN
- Type
- protein
- Length
- 650 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylethanolamine transferase mcr-1
- EC
- 2.7.-.-
- UniProt
- A0A0R6L508
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosphatidylethanolamine transferase mcr-1 (EC 2.7.-.-) | protein | 325 | 31% helix, 18% strand | A0A0R6L508 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 763 | 0.84 | 0.88 | 93 | empty |
| 2 | 113 | 0.54 | 0.83 | 18 | GOL |
| 3 | 120 | 0.51 | 0.81 | 20 | GOL |
| 4 | 146 | 0.50 | 0.79 | 27 | empty |
| 5 | 122 | 0.44 | 0.77 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 971 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 2 modified (disulfide, phosphorylation).
Compared structures
- 5LRN · Structure of mono-zinc MCR-1 in P21 space group · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0R6L508
- Elsewhere: RCSB PDB 5LRN · PDBe 5LRN · UniProt A0A0R6L508
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