MolNFT v1 · #125987 · protein
Kallikrein-related peptidase 10 complex with ZN2+
5LPE · Kallikrein-10: “Kallikrein-related peptidase 10 complex with ZN2+”. X-ray diffraction, 2 ligands (ZN, SO4), 2 pockets (best druggability 0.74). MolNFT v1 #125987 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LPE
- Type
- protein
- Length
- 406 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kallikrein-10
- EC
- 3.4.21.-
- UniProt
- O43240
- Ligands
- ZN, SO4
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kallikrein-10 (EC 3.4.21.-) | protein | 204 | 10% helix, 37% strand | O43240 |
| B | Kallikrein-10 (EC 3.4.21.-) | protein | 202 | 10% helix, 37% strand | O43240 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 783 | 0.74 | 0.79 | 72 | SO4 |
| 2 | 77 | 0.31 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 612 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43240
- Elsewhere: RCSB PDB 5LPE · PDBe 5LPE · UniProt O43240
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