MolNFT v1 · #125975 · protein

Adhesin domain of the type 1 hopq of helicobacter pylori strain G27

5LP2: “Adhesin domain of the type 1 hopq of helicobacter pylori strain G27”. X-ray diffraction, 10 pockets (best druggability 0.67). MolNFT v1 #125975 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LP2
Type: protein
Length: 1,440 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hopq
UniProt: B5Z8H1
Pockets: 10 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D	Hopq	protein	360	52% helix, 12% strand	B5Z8H1

Pockets

10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	243	0.67	0.84	28	empty
2	227	0.67	0.84	26	empty
3	233	0.67	0.84	27	empty
4	275	0.66	0.83	28	empty
5	403	0.64	0.79	44	empty

Interfaces

3 interfaces between chains.

C–D · 1034 Å² buried · 22 hydrogen bonds · protein-protein
B–A · 1025 Å² buried · 23 hydrogen bonds · protein-protein
B–C · 770 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

5LP2 · Adhesin domain of the type 1 HopQ of Helicobacter pylori strain G27 · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B5Z8H1
Elsewhere: RCSB PDB 5LP2 · PDBe 5LP2 · UniProt B5Z8H1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.