MolNFT v1 · #125923 · protein
Crystal structure of hsf 1608-1749 putative domain 1
5LNL: “Crystal structure of hsf 1608-1749 putative domain 1”. X-ray diffraction, 7 pockets (best druggability 0.78). MolNFT v1 #125923 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LNL
- Type
- protein
- Length
- 1,178 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hsf
- UniProt
- P71401
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 8 distinct chains · 15% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hsf | protein | 131 | 15% helix, 40% strand | P71401 |
| B, G | Hsf | protein | 132 | 15% helix, 43% strand | P71401 |
| C | Hsf | protein | 133 | 15% helix, 40% strand | P71401 |
| D | Hsf | protein | 129 | 16% helix, 40% strand | P71401 |
| E | Hsf | protein | 132 | 15% helix, 39% strand | P71401 |
| F | Hsf | protein | 129 | 16% helix, 40% strand | P71401 |
| H | Hsf | protein | 130 | 15% helix, 42% strand | P71401 |
| I | Hsf | protein | 130 | 15% helix, 43% strand | P71401 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.78 | 0.94 | 32 | empty |
| 2 | 76 | 0.76 | 0.99 | 21 | empty |
| 3 | 90 | 0.76 | 0.98 | 26 | empty |
| 4 | 77 | 0.75 | 0.98 | 21 | empty |
| 5 | 708 | 0.73 | 0.79 | 73 | empty |
Interfaces
25 interfaces between chains.
- A–B · 1832 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 1827 Ų buried · 28 hydrogen bonds · protein-protein
- G–I · 1825 Ų buried · 25 hydrogen bonds · protein-protein
- D–F · 1820 Ų buried · 29 hydrogen bonds · protein-protein
- D–E · 1779 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 5LNL · Crystal structure of Hsf 1608-1749 putative domain 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P71401
- Elsewhere: RCSB PDB 5LNL · PDBe 5LNL · UniProt P71401
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