MolNFT v1 · #125822 · protein
Cryo-EM structure of the tc toxin TCDA1 in its pore state (obtained by flexible fitting)
5LKH: “Cryo-EM structure of the tc toxin TCDA1 in its pore state (obtained by flexible fitting)”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #125822 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LKH
- Type
- protein
- Length
- 4,740 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TCDA1
- UniProt
- Q9RN43
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | TCDA1 | protein | 948 | 39% helix, 21% strand | Q9RN43 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 713 | 0.77 | 0.82 | 96 | empty |
| 2 | 742 | 0.77 | 0.81 | 98 | empty |
| 3 | 890 | 0.77 | 0.80 | 106 | empty |
| 4 | 758 | 0.77 | 0.81 | 84 | empty |
| 5 | 275 | 0.74 | 0.87 | 45 | empty |
Compared structures
- 5LKH · Cryo-EM structure of the Tc toxin TcdA1 in its pore state (obtained by flexible fitting) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9RN43
- Elsewhere: RCSB PDB 5LKH · PDBe 5LKH · UniProt Q9RN43
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