MolNFT v1 · #12582 · protein
Solution structure of TGF-B1, NMR, models 1-17 of 33 structures
1KLA · Transforming growth factor-beta 1: “Solution structure of TGF-B1, NMR, models 1-17 of 33 structures”. Solution nmr, 1 pocket (best druggability 0.37). MolNFT v1 #12582 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1KLA
- Type
- protein
- Length
- 224 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transforming growth factor-beta 1
- UniProt
- P01137
- Pockets
- 1 · best druggability 0.37
Structure
solution nmr · 1 distinct chain · 11% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transforming growth factor-beta 1 | protein | 112 | 11% helix, 34% strand | P01137 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.37 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1416 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 1KLA · Solution structure of TGF-B1, NMR, models 1-17 of 33 structures · the same entry in another collection · chain A against A, TM-score 1.00
- P01137 · AlphaFold monomer V2.0 prediction for transforming growth factor beta-1 proprotein… · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01137
- Elsewhere: RCSB PDB 1KLA · PDBe 1KLA · UniProt P01137
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