MolNFT v1 · #125738 · protein

PB3 domain of drosophila melanogaster PLK4 (sak)

5LHX · SERINE/THREONINE-protein kinase PLK4: “PB3 domain of drosophila melanogaster PLK4 (sak)”. X-ray diffraction, 2 pockets (best druggability 0.40). MolNFT v1 #125738 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LHX
Type: protein
Length: 172 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase PLK4
EC: 2.7.11.21
UniProt: O97143
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21)	protein	87	20% helix, 34% strand	O97143
B	SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21)	protein	85	20% helix, 32% strand	O97143

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.40	0.77	21	empty
2	80	0.34	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 595 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

5LHX · PB3 Domain of Drosophila melanogaster PLK4 (Sak) · the same entry in another collection · chain A against A, TM-score 1.00
O97143 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O97143) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O97143
Elsewhere: RCSB PDB 5LHX · PDBe 5LHX · UniProt O97143

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