MolNFT v1 · #125670 · protein

Zinc bound dimer of the fragment of human amyloid-beta peptide with ALZHEIMER'S disease pathogenic taiwanese mutation D7H

5LFY · Amyloid beta A4 protein: “Zinc bound dimer of the fragment of human amyloid-beta peptide with ALZHEIMER'S disease pathogenic taiwanese…”. Solution nmr, 2 ligands (ZN, NH2). MolNFT v1 #125670 on GenesisL1: 3D structure, binding sites…

PDB: 5LFY
Type: protein
Length: 20 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Amyloid beta A4 protein
UniProt: L7XE61
Ligands: ZN, NH2

Structure

solution nmr · 1 distinct chain · 40% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Amyloid beta A4 protein	protein	10	40% helix, 0% strand	L7XE61

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B
NH2 · Amino group · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 173 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

5LFY · Zinc bound dimer of the fragment of human amyloid-beta peptide with Alzheimer's disease… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt L7XE61
Elsewhere: RCSB PDB 5LFY · PDBe 5LFY · UniProt L7XE61

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