MolNFT v1 · #125661 · protein
Crystal structure of the bacterial proteasome activator bpa of mycobacterium tuberculosis (space group P6322, semet)
5LFP: “Crystal structure of the bacterial proteasome activator bpa of mycobacterium tuberculosis (space group P6322…”. X-ray diffraction, 4 pockets (best druggability 0.58). MolNFT v1 #125661 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5LFP
- Type
- protein
- Length
- 432 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bacterial proteasome activator
- UniProt
- P9WKX3
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Bacterial proteasome activator | protein | 108 | 79% helix, 0% strand | P9WKX3 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.58 | 0.76 | 51 | empty |
| 2 | 122 | 0.41 | 0.75 | 23 | empty |
| 3 | 55 | 0.40 | 0.81 | 10 | empty |
| 4 | 54 | 0.35 | 0.78 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1127 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 1125 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1104 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 5LFP · Crystal Structure of the Bacterial Proteasome Activator Bpa of Mycobacterium tuberculosis… · the same entry in another collection · chain D against D, TM-score 1.00
- P9WKX3 · AlphaFold monomer V2.0 prediction for bacterial proteasome activator (P9WKX3) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WKX3
- Elsewhere: RCSB PDB 5LFP · PDBe 5LFP · UniProt P9WKX3
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