MolNFT v1 · #125419 · protein
Structure of UAF1
5L8E · Wd repeat-containing protein 48: “Structure of UAF1”. X-ray diffraction, 8 pockets (best druggability 0.87). MolNFT v1 #125419 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5L8E
- Type
- protein
- Length
- 1,039 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 48; Unknown
- UniProt
- Q8TAF3
- Pockets
- 8 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Wd repeat-containing protein 48 | protein | 517 | 9% helix, 42% strand | Q8TAF3 |
| C | Unknown | protein | 5 | 0% helix, 60% strand | — |
Ligands and binding sites
- GOL · Glycerol · additive · 14 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1057 | 0.87 | 0.89 | 114 | empty |
| 2 | 755 | 0.84 | 0.87 | 78 | GOL |
| 3 | 558 | 0.84 | 0.89 | 65 | empty |
| 4 | 173 | 0.49 | 0.77 | 26 | GOL |
| 5 | 188 | 0.47 | 0.75 | 35 | GOL |
Interfaces
2 interfaces between chains.
- A–B · 1404 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 251 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TAF3
- Elsewhere: RCSB PDB 5L8E · PDBe 5L8E · UniProt Q8TAF3
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