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MolNFT v1 · #125405 · protein

Structure of exuperantia exo-like and SAM-like domains

5L80 · Maternal protein EXUPERANTIA,MATERNAL protein exuperantia: “Structure of exuperantia exo-like and SAM-like domains”. X-ray diffraction, 7 pockets (best druggability 0.70). MolNFT v1 #125405 on GenesisL1: 3D structure, binding sites…

PDB
5L80
Type
protein
Length
570 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Maternal protein EXUPERANTIA,MATERNAL protein exuperantia
UniProt
P28750
Pockets
7 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 18% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AMaternal protein EXUPERANTIA,MATERNAL protein exuperantiaprotein30151% helix, 18% strandP28750
BMaternal protein EXUPERANTIA,MATERNAL protein exuperantiaprotein26948% helix, 19% strandP28750

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
15930.700.7956empty
23890.600.7650empty
3980.550.8419empty
41410.500.7920empty
51020.390.7621empty

Interfaces

1 interface between chains.

  • A–B · 1433 Ų buried · 14 hydrogen bonds · protein-protein

Compared structures

  • 5L80 · Structure of Exuperantia EXO-like and SAM-like domains · the same entry in another collection · chain A against A, TM-score 1.00
  • P28750 · AlphaFold monomer V2.0 prediction for maternal protein exuperantia (P28750) · a predicted model of the same protein · chain B against A, TM-score 0.85

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