MolNFT v1 · #125319 · protein

Plexin A4 full extracellular region, domains 1 to 8 modeled, data to 8 ångström, spacegroup P2(1)

5L5L · Plexin-A4: “Plexin A4 full extracellular region, domains 1 to 8 modeled, data to 8 ångström, spacegroup P2(1)”. X-ray diffraction, 20 pockets (best druggability 0.69). MolNFT v1 #125319 on GenesisL1: 3D structure, binding sites and…

PDB: 5L5L
Type: protein
Length: 1,915 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plexin-A4
UniProt: Q80UG2
Pockets: 20 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plexin-A4	protein	1000	7% helix, 40% strand	Q80UG2
B	Plexin-A4	protein	915	8% helix, 38% strand	Q80UG2

Pockets

20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	532	0.69	0.79	43	empty
2	553	0.69	0.78	45	empty
3	66	0.68	0.95	23	empty
4	108	0.62	0.88	34	empty
5	275	0.62	0.80	30	empty

Modifications

Observed in the structure: 43 disulfide (disulfide).

Compared structures

5L5L · Plexin A4 full extracellular region, domains 1 to 8 modeled, data to 8 angstrom… · the same entry in another collection · chain A against A, TM-score 1.00
Q80UG2 · AlphaFold monomer V2.0 prediction for plexin-A4 (Q80UG2) · a predicted model of the same protein · chain B against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q80UG2
Elsewhere: RCSB PDB 5L5L · PDBe 5L5L · UniProt Q80UG2

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