MolNFT v1 · #125256 · protein

D11 bound igf-II

5L3L · Insulin-like growth factor II: “D11 bound igf-II”. Solution nmr, 1 pocket (best druggability 0.33). MolNFT v1 #125256 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5L3L
Type: protein
Length: 67 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin-like growth factor II
UniProt: P01344
Pockets: 1 · best druggability 0.33

Structure

solution nmr · 1 distinct chain · 39% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin-like growth factor II	protein	67	39% helix, 3% strand	P01344

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.33	0.75	14	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

5L3L · D11 bound IGF-II · the same entry in another collection · chain A against A, TM-score 1.00
P01344 · AlphaFold monomer V2.0 prediction for insulin-like growth factor II (P01344) · a predicted model of the same protein · chain A against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01344
Elsewhere: RCSB PDB 5L3L · PDBe 5L3L · UniProt P01344

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.