MolNFT v1 · #125228 · protein
The X-ray co-crystal structure of human CDK6 and ribociclib.
5L2T · Cyclin-dependent kinase 6: “The X-ray co-crystal structure of human CDK6 and ribociclib.”. X-ray diffraction, 1 ligand (6ZZ), 2 pockets (best druggability 0.71). MolNFT v1 #125228 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5L2T
- Type
- protein
- Length
- 261 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin-dependent kinase 6
- EC
- 2.7.11.22
- UniProt
- Q00534
- Ligands
- 6ZZ
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclin-dependent kinase 6 (EC 2.7.11.22) | protein | 261 | 38% helix, 15% strand | Q00534 |
Ligands and binding sites
- 6ZZ · 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 377 | 0.71 | 0.82 | 44 | 6ZZ |
| 2 | 56 | 0.34 | 0.77 | 15 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00534
- Elsewhere: RCSB PDB 5L2T · PDBe 5L2T · UniProt Q00534
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.