MolNFT v1 · #125212 · protein

Streptococcal surface adhesin - csha NR2

5L2D · Surface-associated protein csha: “Streptococcal surface adhesin - csha NR2”. X-ray diffraction, 2 pockets (best druggability 0.80). MolNFT v1 #125212 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5L2D
Type: protein
Length: 487 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Surface-associated protein csha
UniProt: A8AWJ3
Pockets: 2 · best druggability 0.80

Structure

x-ray diffraction · 3 distinct chains · 13% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Surface-associated protein csha	protein	210	13% helix, 32% strand	A8AWJ3
B	Surface-associated protein csha	protein	211	14% helix, 33% strand	A8AWJ3
C, D	Surface-associated protein csha	protein	33	0% helix, 67% strand	A8AWJ3

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1071	0.80	0.81	79	empty
2	69	0.55	0.87	28	empty

Interfaces

3 interfaces between chains.

B–D · 2771 Å² buried · 64 hydrogen bonds · protein-protein
A–C · 2756 Å² buried · 63 hydrogen bonds · protein-protein
A–B · 389 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5L2D · Streptococcal surface adhesin - CshA NR2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A8AWJ3
Elsewhere: RCSB PDB 5L2D · PDBe 5L2D · UniProt A8AWJ3

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