MolNFT v1 · #125205 · protein
Crystal structure of the complex between the N-terminal SH3 domain of crkii and a proline-rich ligand
5L23 · Adapter molecule crk: “Crystal structure of the complex between the N-terminal SH3 domain of crkii and a proline-rich ligand”. X-ray diffraction, 2 ligands (ACE, NH2). MolNFT v1 #125205 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5L23
- Type
- protein
- Length
- 73 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adapter molecule crk; C3G derived peptide
- UniProt
- Q64010
- Ligands
- ACE, NH2
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adapter molecule crk | protein | 58 | 5% helix, 45% strand | Q64010 |
| B | C3G derived peptide | protein | 15 | 0% helix, 0% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · chains B
- NH2 · Amino group · ion · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 582 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 5L23 · Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a… · the same entry in another collection · chain A against A, TM-score 1.00
- Q64010 · AlphaFold monomer V2.0 prediction for adapter molecule crk (Q64010) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q64010
- Elsewhere: RCSB PDB 5L23 · PDBe 5L23 · UniProt Q64010
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