MolNFT v1 · #124827 · protein

Structure of NS5 methyltransferase from zika virus bound to S- adenosylmethionine and 7-methyl-guanosine-5'-diphosphate

5KQS: “Structure of NS5 methyltransferase from zika virus bound to S- adenosylmethionine and…”. X-ray diffraction, 3 ligands (M7G, SAM, PO4), 1 pocket (best druggability 0.65). MolNFT v1 #124827 on GenesisL1: 3D structure, binding sites…

PDB: 5KQS
Type: protein
Length: 260 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methyltransferase
UniProt: H9A910
Ligands: M7G, SAM, PO4
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methyltransferase	protein	260	37% helix, 16% strand	H9A910

Ligands and binding sites

M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · ligand · chains A
SAM · S-adenosylmethionine · ligand · chains A
PO4 · Phosphate ion · ion · chains A
GOL · Glycerol · additive · 4 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	512	0.65	0.77	48	SAM, PO4

Compared structures

5KQS · Structure of NS5 methyltransferase from Zika virus bound to S-adenosylmethionine and… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H9A910
Elsewhere: RCSB PDB 5KQS · PDBe 5KQS · UniProt H9A910

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