MolNFT v1 · #124777 · protein
Crystal structure of the curacin biosynthetic pathway hmg synthase in complex with apo donor-acp
5KP6 · Curd: “Crystal structure of the curacin biosynthetic pathway hmg synthase in complex with apo donor-acp”. X-ray diffraction, 3 pockets (best druggability 0.75). MolNFT v1 #124777 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5KP6
- Type
- protein
- Length
- 482 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Curd; Curb
- EC
- 2.3.3.10
- UniProt
- F4Y432, Q6DNF1
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Curd (EC 2.3.3.10) | protein | 404 | 42% helix, 26% strand | F4Y432 |
| B | Curb | protein | 78 | 58% helix, 0% strand | Q6DNF1 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 581 | 0.75 | 0.82 | 63 | empty |
| 2 | 68 | 0.53 | 0.86 | 16 | empty |
| 3 | 99 | 0.40 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 852 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 5KP6 · Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Apo… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F4Y432
- Every structure of UniProt Q6DNF1
- Elsewhere: RCSB PDB 5KP6 · PDBe 5KP6 · UniProt F4Y432 · UniProt Q6DNF1
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