MolNFT v1 · #124747 · protein
Structure of escherichia COLI zapd bound to the C-terminal tail of ftsz
5KOA · Cell division protein zapd: “Structure of escherichia COLI zapd bound to the C-terminal tail of ftsz”. X-ray diffraction, 10 pockets (best druggability 0.69). MolNFT v1 #124747 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5KOA
- Type
- protein
- Length
- 504 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein zapd; C-terminal tail of ftsz
- UniProt
- B7MAM4
- Pockets
- 10 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cell division protein zapd | protein | 246 | 50% helix, 20% strand | B7MAM4 |
| D | C-terminal tail of ftsz | protein | 12 | 25% helix, 8% strand | — |
Pockets
10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 234 | 0.69 | 0.86 | 40 | empty |
| 2 | 173 | 0.50 | 0.77 | 22 | empty |
| 3 | 148 | 0.47 | 0.77 | 26 | empty |
| 4 | 137 | 0.43 | 0.76 | 20 | empty |
| 5 | 122 | 0.38 | 0.74 | 21 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1917 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 467 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5KOA · Structure of Escherichia coli ZapD bound to the C-terminal tail of FtsZ · the same entry in another collection · chain A against A, TM-score 1.00
- B7MAM4 · AlphaFold monomer V2.0 prediction for cell division protein zapd (B7MAM4) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B7MAM4
- Elsewhere: RCSB PDB 5KOA · PDBe 5KOA · UniProt B7MAM4
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