MolNFT v1 · #124741 · protein

Bromodomain from trypanosoma brucei TB427.10.8150

5KO4 · Putative uncharacterized protein: “Bromodomain from trypanosoma brucei TB427.10.8150”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.65). MolNFT v1 #124741 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5KO4
Type: protein
Length: 201 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative uncharacterized protein
UniProt: Q38AE9
Ligands: SO4
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative uncharacterized protein	protein	101	65% helix, 0% strand	Q38AE9
B	Putative uncharacterized protein	protein	100	66% helix, 0% strand	Q38AE9

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	304	0.65	0.81	39	empty

Interfaces

1 interface between chains.

A–B · 722 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5KO4 · Bromodomain from Trypanosoma brucei Tb427.10.8150 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q38AE9
Elsewhere: RCSB PDB 5KO4 · PDBe 5KO4 · UniProt Q38AE9

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