MolNFT v1 · #124655 · protein

Crystal structure of trypanosoma brucei procyclic specific surface antigen-2

5KLH · Surface glycoprotein: “Crystal structure of trypanosoma brucei procyclic specific surface antigen-2”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.63). MolNFT v1 #124655 on GenesisL1: 3D structure, binding sites…

PDB: 5KLH
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Surface glycoprotein
UniProt: Q26806
Ligands: SO4
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Surface glycoprotein	protein	221	19% helix, 43% strand	Q26806
B	Surface glycoprotein	protein	215	19% helix, 40% strand	Q26806

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	179	0.63	0.84	33	empty
2	142	0.49	0.78	33	empty
3	62	0.24	0.71	15	empty

Interfaces

1 interface between chains.

A–B · 744 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

5KLH · Crystal Structure of Trypanosoma brucei Procyclic Specific Surface Antigen-2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q26806
Elsewhere: RCSB PDB 5KLH · PDBe 5KLH · UniProt Q26806

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