MolNFT v1 · #124571 · protein
The novel P300/CBP inhibitor a-485 uncovers a unique mechanism of action to target ar in castrate resistant prostate cancer
5KJ2: “The novel P300/CBP inhibitor a-485 uncovers a unique mechanism of action to target ar in castrate resistant…”. X-ray diffraction, 2 ligands (6TF, NA). MolNFT v1 #124571 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5KJ2
- Type
- protein
- Length
- 323 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q09472
- Ligands
- 6TF, NA
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 323 | — | Q09472 |
Ligands and binding sites
- 6TF · N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1, 1-trifluoropropan-2-yl]acetamide · ligand · chains A
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5KJ2 · The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q09472 · AlphaFold monomer V2.0 prediction for histone acetyltransferase P300 (Q09472) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09472
- Elsewhere: RCSB PDB 5KJ2 · PDBe 5KJ2 · UniProt Q09472
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