Crystal structure of the N-terminal fragment of tropomyosin isoform TPM1.1 at 1.5 a resolution

Structure

x-ray diffraction · 1 distinct chain · 91% helix, 0% strand (DSSP).

Ligands and binding sites

• PEG · Di(hydroxyethyl)ether · additive · 4 copies · chains B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

• A–C · 1358 Ų buried · 12 hydrogen bonds · protein-protein
• B–D · 1342 Ų buried · 14 hydrogen bonds · protein-protein
• C–D · 333 Ų buried · 7 hydrogen bonds · protein-protein
• B–C · 60 Ų buried · 1 hydrogen bond · protein-protein
• A–D · 38 Ų buried · 1 hydrogen bond · protein-protein

Compared structures

• 5KHT · Crystal structure of the N-terminal fragment of tropomyosin isoform Tpm1.1 at 1.5 A… · the same entry in another collection · chain A against A, TM-score 1.00
• P09493 · AlphaFold monomer V2.0 prediction for tropomyosin alpha-1 chain (P09493) · a predicted model of the same protein · chain A against A, TM-score 0.90
• P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain C against A, TM-score 0.87

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P09493
• Every structure of UniProt P03069
• Elsewhere: RCSB PDB 5KHT · PDBe 5KHT · UniProt P09493 · UniProt P03069