MolNFT v1 · #1242 · protein
Structure of human adenovirus 2 proteinase with its 11 amino acid cofactor
1AVP · Adenoviral proteinase: “Structure of human adenovirus 2 proteinase with its 11 amino acid cofactor”. X-ray diffraction, 1 pocket (best druggability 0.39). MolNFT v1 #1242 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1AVP
- Type
- protein
- Length
- 215 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenoviral proteinase
- UniProt
- P03252, P03274
- Pockets
- 1 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenoviral proteinase | protein | 204 | 38% helix, 17% strand | P03252 |
| B | Adenoviral proteinase | protein | 11 | 0% helix, 64% strand | P03274 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.39 | 0.76 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 841 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1AVP · Structure of human adenovirus 2 proteinase with its 11 amino acid cofactor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03252
- Every structure of UniProt P03274
- Elsewhere: RCSB PDB 1AVP · PDBe 1AVP · UniProt P03252 · UniProt P03274
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