MolNFT v1 · #124039 · protein

Crystal structure of retinoic acid receptor-related orphan receptor (ror) gamma ligand binding domain

5K38 · Nuclear receptor ror-gamma: “Crystal structure of retinoic acid receptor-related orphan receptor (ror) gamma ligand binding domain”. X-ray diffraction, 8 pockets (best druggability 0.83). MolNFT v1 #124039 on GenesisL1: 3D…

PDB: 5K38
Type: protein
Length: 453 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear receptor ror-gamma
UniProt: P51449
Pockets: 8 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear receptor ror-gamma	protein	227	71% helix, 4% strand	P51449
B	Nuclear receptor ror-gamma	protein	226	73% helix, 4% strand	P51449

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	388	0.83	0.91	35	empty
2	373	0.81	0.90	35	empty
3	396	0.54	0.72	41	empty
4	103	0.46	0.80	16	empty
5	95	0.41	0.78	18	empty

Interfaces

1 interface between chains.

A–B · 78 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5K38 · Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51449
Elsewhere: RCSB PDB 5K38 · PDBe 5K38 · UniProt P51449

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