MolNFT v1 · #123924 · protein
Structure of wild type amidase at high temperature at 2.5 ångström resolution
5JZO · Intracellular PROTEASE/AMIDASE: “Structure of wild type amidase at high temperature at 2.5 ångström resolution”. X-ray diffraction, 15 pockets (best druggability 0.81). MolNFT v1 #123924 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5JZO
- Type
- protein
- Length
- 1,686 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Intracellular PROTEASE/AMIDASE
- EC
- 4.2.1.130
- UniProt
- A0A0H3AFW5
- Pockets
- 15 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Intracellular PROTEASE/AMIDASE (EC 4.2.1.130) | protein | 281 | 39% helix, 17% strand | A0A0H3AFW5 |
Pockets
15 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 843 | 0.81 | 0.84 | 105 | empty |
| 2 | 147 | 0.74 | 0.92 | 39 | empty |
| 3 | 707 | 0.73 | 0.79 | 70 | empty |
| 4 | 402 | 0.64 | 0.78 | 53 | empty |
| 5 | 179 | 0.58 | 0.81 | 26 | empty |
Interfaces
10 interfaces between chains.
- C–D · 1101 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 1089 Ų buried · 20 hydrogen bonds · protein-protein
- E–F · 921 Ų buried · 18 hydrogen bonds · protein-protein
- B–F · 480 Ų buried · 11 hydrogen bonds · protein-protein
- C–F · 453 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 5JZO · Structure of wild type amidase at high temperature at 2.5 Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H3AFW5
- Elsewhere: RCSB PDB 5JZO · PDBe 5JZO · UniProt A0A0H3AFW5
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