MolNFT v1 · #12374 · protein

Crystal structure of mouse TESTIS/BRAIN RNA-binding protein (tb-rbp)

1KEY · Translin: “Crystal structure of mouse TESTIS/BRAIN RNA-binding protein (tb-rbp)”. X-ray diffraction, 10 pockets (best druggability 0.70). MolNFT v1 #12374 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1KEY
Type: protein
Length: 854 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translin
UniProt: Q62348
Pockets: 10 · best druggability 0.70

Structure

x-ray diffraction · 4 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Translin	protein	212	77% helix, 0% strand	Q62348
B	Translin	protein	221	76% helix, 0% strand	Q62348
C	Translin	protein	210	75% helix, 0% strand	Q62348
D	Translin	protein	211	78% helix, 0% strand	Q62348

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	603	0.70	0.78	39	empty
2	580	0.68	0.78	41	empty
3	631	0.67	0.76	77	empty
4	322	0.54	0.75	41	empty
5	201	0.50	0.77	26	empty

Interfaces

5 interfaces between chains.

C–D · 1768 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 1767 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 728 Å² buried · 8 hydrogen bonds · protein-protein
B–D · 705 Å² buried · 6 hydrogen bonds · protein-protein
A–D · 86 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1KEY · Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP) · the same entry in another collection · chain C against C, TM-score 1.00
Q62348 · AlphaFold monomer V2.0 prediction for translin (Q62348) · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62348
Elsewhere: RCSB PDB 1KEY · PDBe 1KEY · UniProt Q62348

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