MolNFT v1 · #123680 · protein

Crystal structure of native laccase from thermus thermophilus HB27

5JRR: “Crystal structure of native laccase from thermus thermophilus HB27”. X-ray diffraction, 2 ligands (CU, OXY), 4 pockets (best druggability 0.61). MolNFT v1 #123680 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5JRR
Type: protein
Length: 439 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Laccase
EC: 1.10.3.2
UniProt: Q72HW2
Ligands: CU, OXY
Pockets: 4 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Laccase (EC 1.10.3.2)	protein	439	6% helix, 48% strand	Q72HW2

Ligands and binding sites

CU · Copper (II) ion · metal · 4 copies · chains A
OXY · Oxygen molecule · ion · chains A
MPD · (4S)-2-methyl-2,4-pentanediol · additive · 13 copies · chains A
MRD · (4R)-2-methylpentane-2,4-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	278	0.61	0.79	30	MPD
2	155	0.46	0.76	28	MPD
3	88	0.40	0.78	21	empty
4	63	0.30	0.74	18	MPD

Compared structures

5JRR · Crystal structure of native laccase from Thermus thermophilus HB27 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q72HW2
Elsewhere: RCSB PDB 5JRR · PDBe 5JRR · UniProt Q72HW2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.