MolNFT v1 · #123417 · protein

Fic-1 (AA134 - 508 E274G) from C. elegans

5JJ7 · Adenosine monophosphate-protein transferase ficd homolog: “Fic-1 (AA134 - 508 E274G) from C. elegans”. X-ray diffraction, 1 ligand (SO4), 10 pockets (best druggability 0.46). MolNFT v1 #123417 on GenesisL1: 3D structure, binding…

PDB: 5JJ7
Type: protein
Length: 660 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenosine monophosphate-protein transferase ficd homolog
EC: 2.7.7.-
UniProt: Q23544
Ligands: SO4
Pockets: 10 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adenosine monophosphate-protein transferase ficd homolog (EC 2.7.7.-)	protein	330	69% helix, 0% strand	Q23544
B	Adenosine monophosphate-protein transferase ficd homolog (EC 2.7.7.-)	protein	330	67% helix, 0% strand	Q23544

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.46	0.76	26	empty
2	118	0.45	0.77	17	empty
3	173	0.45	0.75	29	SO4
4	106	0.44	0.78	15	empty
5	168	0.44	0.74	24	empty

Interfaces

1 interface between chains.

A–B · 684 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

5JJ7 · Fic-1 (aa134 - 508 E274G) from C. elegans · the same entry in another collection · chain A against A, TM-score 1.00
Q23544 · AlphaFold monomer V2.0 prediction for protein adenylyltransferase fic-1 (Q23544) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q23544
Elsewhere: RCSB PDB 5JJ7 · PDBe 5JJ7 · UniProt Q23544

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