MolNFT v1 · #123306 · protein
E. COLI ecfict in complex with ecfica mutant E28G
5JFZ · Probable adenosine monophosphate-protein transferase fic: “E. COLI ecfict in complex with ecfica mutant E28G”. X-ray diffraction, 7 pockets (best druggability 0.75). MolNFT v1 #123306 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5JFZ
- Type
- protein
- Length
- 686 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable adenosine monophosphate-protein transferase fic; Uncharacterized protein yhfg
- EC
- 2.7.7.-
- UniProt
- P20605, P0ADX5
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 5 distinct chains · 59% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable adenosine monophosphate-protein transferase fic (EC 2.7.7.-) | protein | 181 | 57% helix, 3% strand | P20605 |
| B, F | Uncharacterized protein yhfg | protein | 49 | 73% helix, 0% strand | P0ADX5 |
| C | Probable adenosine monophosphate-protein transferase fic (EC 2.7.7.-) | protein | 180 | 57% helix, 3% strand | P20605 |
| D | Uncharacterized protein yhfg | protein | 47 | 72% helix, 0% strand | P0ADX5 |
| E | Probable adenosine monophosphate-protein transferase fic (EC 2.7.7.-) | protein | 180 | 57% helix, 2% strand | P20605 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 846 | 0.75 | 0.79 | 67 | empty |
| 2 | 435 | 0.59 | 0.75 | 52 | empty |
| 3 | 306 | 0.56 | 0.76 | 36 | empty |
| 4 | 316 | 0.54 | 0.75 | 38 | empty |
| 5 | 95 | 0.34 | 0.74 | 21 | empty |
Interfaces
6 interfaces between chains.
- E–F · 1614 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1567 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1432 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 544 Ų buried · 8 hydrogen bonds · protein-protein
- C–E · 248 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5JFZ · E. coli EcFicT in complex with EcFicA mutant E28G · the same entry in another collection · chain F against F, TM-score 1.00
- P20605 · AlphaFold monomer V2.0 prediction for probable protein adenylyltransferase fic (P20605) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P0ADX5 · AlphaFold monomer V2.0 prediction for uncharacterized protein yhfg (P0ADX5) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20605
- Every structure of UniProt P0ADX5
- Elsewhere: RCSB PDB 5JFZ · PDBe 5JFZ · UniProt P20605 · UniProt P0ADX5
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