MolNFT v1 · #123263 · protein
Complex of irf-3 with cbp
5JEM · Interferon regulatory factor 3: “Complex of irf-3 with cbp”. X-ray diffraction, 17 pockets (best druggability 0.78). MolNFT v1 #123263 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5JEM
- Type
- protein
- Length
- 977 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon regulatory factor 3; Creb-binding protein
- EC
- 2.3.1.48
- UniProt
- Q14653, Q92793
- Pockets
- 17 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E | Interferon regulatory factor 3 | protein | 203 | 21% helix, 32% strand | Q14653 |
| C, D, F, H | Creb-binding protein (EC 2.3.1.48) | protein | 42 | 74% helix, 0% strand | Q92793 |
| G | Interferon regulatory factor 3 | protein | 200 | 22% helix, 34% strand | Q14653 |
Pockets
17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 449 | 0.78 | 0.86 | 50 | empty |
| 2 | 714 | 0.78 | 0.82 | 83 | empty |
| 3 | 322 | 0.76 | 0.87 | 33 | empty |
| 4 | 343 | 0.73 | 0.85 | 33 | empty |
| 5 | 266 | 0.62 | 0.80 | 26 | empty |
Interfaces
17 interfaces between chains.
- E–G · 2048 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 2005 Ų buried · 36 hydrogen bonds · protein-protein
- B–D · 1010 Ų buried · 15 hydrogen bonds · protein-protein
- G–H · 989 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 940 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5JEM · Complex of IRF-3 with CBP · the same entry in another collection · chain H against H, TM-score 1.00
- Q14653 · AlphaFold monomer V2.0 prediction for interferon regulatory factor 3 (Q14653) · a predicted model of the same protein · chain G against A, TM-score 0.89
- Q92793 · AlphaFold monomer V2.0 prediction for creb-binding protein (Q92793) · a predicted model of the same protein · chain D against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14653
- Every structure of UniProt Q92793
- Elsewhere: RCSB PDB 5JEM · PDBe 5JEM · UniProt Q14653 · UniProt Q92793
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