MolNFT v1 · #123261 · protein
Phosphorylated mavs in complex with irf-3
5JEK · Interferon regulatory factor 3: “Phosphorylated mavs in complex with irf-3”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #123261 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5JEK
- Type
- protein
- Length
- 498 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon regulatory factor 3; Mavs peptide
- UniProt
- Q14653
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 23% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Interferon regulatory factor 3 | protein | 234 | 26% helix, 30% strand | Q14653 |
| C | Mavs peptide | protein | 14 | 0% helix, 7% strand | — |
| D | Mavs peptide | protein | 16 | 0% helix, 6% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 689 | 0.72 | 0.79 | 87 | empty |
| 2 | 59 | 0.27 | 0.73 | 11 | empty |
Interfaces
4 interfaces between chains.
- A–B · 711 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 539 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 535 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 80 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14653
- Elsewhere: RCSB PDB 5JEK · PDBe 5JEK · UniProt Q14653
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