MolNFT v1 · #123085 · protein

Dimerization domain of cytoplasmic ACTIVATION/PROLIFERATION-associated protein-2 (caprin-2)

5J97: “Dimerization domain of cytoplasmic ACTIVATION/PROLIFERATION-associated protein-2 (caprin-2)”. X-ray diffraction, 2 pockets (best druggability 0.65). MolNFT v1 #123085 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5J97
Type: protein
Length: 247 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caprin-2
UniProt: Q6IMN6
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Caprin-2	protein	125	67% helix, 3% strand	Q6IMN6
B	Caprin-2	protein	122	64% helix, 3% strand	Q6IMN6

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	391	0.65	0.79	29	empty
2	85	0.50	0.83	11	empty

Interfaces

1 interface between chains.

A–B · 1430 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

5J97 · Dimerization domain of cytoplasmic activation/proliferation-associated protein-2… · the same entry in another collection · chain A against A, TM-score 1.00
Q6IMN6 · AlphaFold monomer V2.0 prediction for caprin-2 (Q6IMN6) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6IMN6
Elsewhere: RCSB PDB 5J97 · PDBe 5J97 · UniProt Q6IMN6

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