MolNFT v1 · #12306 · protein
Crystal structure of antibody PC282
1KCV · PC282 immunoglobulin: “Crystal structure of antibody PC282”. X-ray diffraction, 4 pockets (best druggability 0.52). MolNFT v1 #12306 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1KCV
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PC282 immunoglobulin
- UniProt
- P01837, P18532
- Pockets
- 4 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | PC282 immunoglobulin | protein | 214 | 6% helix, 51% strand | P01837 |
| H | PC282 immunoglobulin | protein | 217 | 4% helix, 51% strand | P18532 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.52 | 0.74 | 44 | empty |
| 2 | 81 | 0.51 | 0.84 | 24 | empty |
| 3 | 94 | 0.40 | 0.77 | 25 | empty |
| 4 | 71 | 0.29 | 0.73 | 23 | empty |
Interfaces
1 interface between chains.
- L–H · 1693 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1KCV · Crystal structure of antibody pc282 · the same entry in another collection · chain L against L, TM-score 1.00
- P01837 · AlphaFold monomer V2.0 prediction for immunoglobulin kappa constant (P01837) · a predicted model of the same protein · chain L against A, TM-score 0.50
- P18532 · AlphaFold monomer V2.0 prediction for ig heavy chain V region 1B43 (P18532) · a predicted model of the same protein · chain H against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01837
- Every structure of UniProt P18532
- Elsewhere: RCSB PDB 1KCV · PDBe 1KCV · UniProt P01837 · UniProt P18532
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